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(4702, 404, 'management_2_bio', '<p> Aradhana Vipra is Head of Microbiology at GangaGen Biotechnologies Private Limited. She joined GangaGen in 2003, and leads the company’s Microbiology team. </p>\r\n\r\n<p> Ms. Vipra has extensive experience in bacteriophage research, including characterization of bacteriophages for various Gram-positive and Gram-negative drug resistant bacteria and product development strategies for phage-based prophylactics. She is well-versed in clinical laboratory guidelines for in-vitro testing of new candidate drugs and acquainted with a range of in-vitro based assays. </p>\r\n\r\n<p> Ms. Vipra holds a Master’s Degree in Microbiology from Department of Microbiology, Nagpur University, India. She has published in peer reviewed journals including Antimicrobial Agents and Chemotherapy, Microbiology, BMC Microbiology, Veterinary Research Communications and phage related research articles in Diseases of Aquatic Microorganisms and Advances in Microbiology. She is an inventor on the patent filed for P128 activity on biofilm. </p>'),
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(5278, 413, 'sections_1_content', '<div id=\"protein-antibiotic-technology\" class=\"gg-light\">\r\n	<div class=\"centerize ctz-lg px-3 py-5 text-center anim-hidden fade-in-up animated visible fadeInUp full-visible\">\r\n		<p class=\"gg-japanese-laurel-text\" style=\"font-size:1.4rem; line-height:2;\">Bacteriocins are a diverse family of protein molecules produced by many Gram positive and Gram negative bacteria with antibacterial activity. Bacteria produce these bacteriocins to inhibit or eliminate other closely related bacteria to eliminate competition. Bacteriocins present a unique family of naturally occurring antibacterial proteins with a potential to be developed into antibiotics.</p>\r\n	</div>\r\n</div>'),
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(5316, 238, 'sections_1_admin_title', 'Lysins Info'),
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(5320, 238, 'sections_1_content', '<div id=\"protein-antibiotic-technology\" class=\"gg-light\">\r\n	<div class=\"centerize ctz-lg px-3 py-5 text-center anim-hidden fade-in-up\">\r\n		<p class=\"gg-japanese-laurel-text\" style=\"font-size:1.4rem; line-height:2;\">Lysins are bacteriophage derived proteins that have antibacterial properties and play important physiological roles during the phage life cycle. These proteins are enzymatic by nature and have either muralytic, proteolytic or hydrolytic activity enabling them to lyse the cell wall of the target bacterium.</p>\r\n	</div>\r\n</div>\r\n\r\n<!-- <div id=\"ectolysin-intro\" class=\"abx-white\">\r\n  <div class=\"centerize ctz-lg px-3 py-5\">\r\n    <div class=\"row\">\r\n      \r\n      <div class=\"col-12 anim-hidden fade-in-up text-center\">\r\n        <h2 class=\"gg-japanese-laurel-text fw-700\">Ectolysins</h2>\r\n        <p class=\"gg-calypso-text\" style=\"line-height:2; font-size:1.4rem;\">Ectolysins help the phage gain entry from outside into the bacterial cell. Endolysins help the phage progeny to burst open &amp; exit the bacterial cell.</p>\r\n        <a href=\"/ectolysin\"><button class=\"gangagen-button\">Learn More</button></a>\r\n      </div>\r\n      \r\n      <div class=\"col-12 col-md-6 anim-hidden fade-in-right text-center\">\r\n        <img src=\"https://via.placeholder.com/250x250/?text=Ectolysin+Image+Goes+Here\" alt=\"ectolysins\" />\r\n      </div>\r\n      \r\n    </div>\r\n  </div>\r\n</div> -->\r\n\r\n<div id=\"lysin-innovation\" class=\"gg-golden-bell abx-white-text\">\r\n  <div class=\"centerize ctz-lg px-3 py-5 text-center\">\r\n    <h2 class=\"anim-hidden fade-in-up\">Lysin Innovations</h2>\r\n    <p class=\"anim-hidden fade-in-up\" style=\"line-height:2; font-size:1.4rem;\">GangaGen has used its proprietary PATP to design novel lysin molecules to target both Gram positive and Gram negative pathogens. The most advanced of these is P128 (Staphtame), an Ectolysin that is active on Staphylococci and progressed to clinical trials in humans.</p>\r\n  </div>\r\n</div>'),
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(6160, 236, 'sections_2_admin_title', 'Gram Negative Bacteriocins'),
(6161, 236, '_sections_2_admin_title', 'field_5e865038f6507'),
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(6164, 236, 'sections_2_content', '<div id=\"gram-negative-bacteriocins\">\r\n  \r\n  <div class=\"gg-japanese-laurel abx-white-text text-center\">\r\n    <div class=\"centerize ctz-lg px-3 py-5 anim-hidden fade-in-up\">\r\n      <h2 class=\"fw-900\">Gram Negative Bacteriocins</h2>\r\n      <p style=\"line-height:2; font-size:1.4rem;\">Bacteriocins from Gram negative bacteria are broadly classified into 3 types based on their size as:</p>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"abx-white\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n\r\n      <div class=\"row\">\r\n        <!-- /wp-content/uploads/2020/09/2a.-Peptide-Bacteriocins.jpg.jpg -->\r\n        <div class=\"col-12 col-md-4 text-center anim hidden fade-in-left\">\r\n          <img style=\"height:190px;\" class=\"mb-3\" src=\"/wp-content/uploads/2020/10/2a-Peptide-Bacteriocins.jpg.jpg\" alt=\"peptide-bacteriocins\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Peptide Bacteriocins</h3>\r\n          <p>Peptide Bacteriocins like microcins of less than 10 kDa size</p>\r\n        </div>\r\n        \r\n        <div class=\"col-12 col-md-4 text-center anim-hidden fade-in-up\">\r\n          <img style=\"height:190px;\" class=\"mb-3\" src=\"/wp-content/uploads/2020/09/2b.-Colicins-Like-Bacteriocins.jpg-e1600372580990.jpg\" alt=\"colicin-like-bacteriocins\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Colicin-Like Bacteriocins (CLB)</h3>\r\n          <p>Colicin-Like Bacteriocins (CLB) of 25 – 80 kDa size</p>\r\n        </div>\r\n        \r\n        <div class=\"col-12 col-md-4 text-center anim-hidden fade-in-right\">\r\n          <img style=\"height:190px;\" class=\"mb-3\" src=\"/wp-content/uploads/2020/10/Lambda-Ur_Tail_model-scaled.jpg\" alt=\"tailocins\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Tailocins</h3>\r\n          <p>Tailocins are high molecular size bacteriocins that resemble the tail structures of bacteriophages </p\r\n        </div>\r\n        \r\n      </div>\r\n      \r\n    </div>\r\n  </div>\r\n  \r\n   <div id=\"how-and-mechanisms\" class=\"px-0 py-0\" style=\"border-top:solid 8px var(--gg-calypso);\">\r\n    <div class=\"row\">\r\n      <div class=\"col-12 col-md-6 abx-white py-5 text-center\">\r\n        <div class=\"centerize ctz-sm\">\r\n        	<h2 class=\"gg-calypso-text fw-900 anim-hidden fade-in-left\">How Does It Work?</h2>\r\n        	<p class=\"gg-calypso-text anim-hidden fade-in-left\" style=\"font-size:1.4rem; line-height:2;\">The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it.</p>\r\n        </div>\r\n      </div>\r\n      <div class=\"col-12 col-md-6 gg-light py-5 text-center\">\r\n        <div class=\"centerize ctz-sm\">\r\n        	<h2 class=\"gg-japanese-laurel-text fw-900 anim-hidden fade-in-right\">Mechanism of Action</h2>\r\n        	<p class=\"gg-japanese-laurel-text anim-hidden fade-in-right\" style=\"font-size:1.4rem; line-height:2;\">The mechanism of killing is through multiple modes such as cell wall damage, cell membrane damage, interfering in metabolic pathways, and DNase or RNase activities.</p>\r\n        </div>\r\n      </div>\r\n    </div>\r\n  </div>\r\n  \r\n  <div id=\"bacteriocin-advantages-header\" class=\"gg-calypso text-center\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n    	<h2 class=\"fw-900 abx-white-text anim-hidden fade-in-up\">Advantages of Bacteriocins</h2>\r\n    	<p class=\"abx-white-text anim-hidden fade-in-up\" style=\"font-size:1.4rem; line-height:2;\">Bacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:</p>\r\n    </div>\r\n  </div>\r\n  \r\n  <div id=\"bacteriocin-advantages\" class=\"gg-light\">\r\n   <div class=\"centerize ctz-md px-3 py-5\">\r\n    \r\n    <ul class=\"fa-ul\">\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Specific</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome.</p>\r\n      </li>\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Resistance Development</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.</p>\r\n      </li>\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Selective</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents.</p>\r\n      </li>\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Modular Architecture</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability.</p>\r\n      </li>\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Low Toxicity</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.</p>\r\n      </li>\r\n      \r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Synergy</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">The potency of bacteriocin can further be enhanced by combining them with standard of care antibiotics.</p>\r\n      </li>\r\n      \r\n    </ul>\r\n  \r\n</div>\r\n    \r\n<div class=\"abx-white\">\r\n   <div class=\"centerize ctz-md px-3 py-5 text-center anim-hidden fade-in-up\">\r\n     <a href=\"https://carb-x.org/\" target=\"_blank\">\r\n       <img src=\"/wp-content/uploads/2020/10/CARB-X_logo.jpg\" alt=\"carb-x-logo\" style=\"width:300px; margin:0 auto; display:inherit;\" />\r\n     </a>\r\n   </div>\r\n</div>'),
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(6288, 433, 'sections_2_content', '<div id=\"gram-negative-bacteriocins\">\r\n  \r\n  <div>\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n      <h2></h2>\r\n      <p>Bacteriocins from Gram negative bacteria are broadly classified into 3 types based on their size as:</p>\r\n    </div>\r\n  </div>\r\n  \r\n  <div>\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n\r\n      <div class=\"row\">\r\n        \r\n        <div class=\"col-12 col-md-4 text-center\">\r\n          <img class=\"mb-3\" src=\"https://via.placeholder.com/150x150?text=Image+Goes+Here\" alt=\"\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Peptide Bacteriocins</h3>\r\n          <p>Peptide Bacteriocins like microcins of less than 10 kDa size</p>\r\n        </div>\r\n        \r\n        <div class=\"col-12 col-md-4 text-center\">\r\n          <img class=\"mb-3\" src=\"https://via.placeholder.com/150x150?text=Image+Goes+Here\" alt=\"\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Colicin-Like Bacteriocins (CLB)</h3>\r\n          <p>Colicin-Like Bacteriocins (CLB) of 25 – 80 kDa size</p>\r\n        </div>\r\n        \r\n        <div class=\"col-12 col-md-4 text-center\">\r\n          <img class=\"mb-3\" src=\"https://via.placeholder.com/150x150?text=Image+Goes+Here\" alt=\"\" />\r\n          <h3 class=\"gg-japanese-laurel-text mb-3\">Tailocins</h3>\r\n          <p>Tailocins which are high molecular size bacteriocins that resemble the tail structures of bacteriophages.</p>\r\n        </div>\r\n        \r\n      </div>\r\n      \r\n    </div>\r\n  </div>\r\n  \r\n</div>'),
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(8223, 484, 'sections_2_content', '<div id=\"ectolysin-advantages\" class=\"gg-light\">\r\n  <div class=\"centerize ctz-lg px-3 py-5\">\r\n    <div class=\"text-center\">\r\n    	<h2 class=\"fw-900 gg-calypso-text anim-hidden fade-in-up\">Advantages of Ectolysins over Antibiotics</h2>\r\n    	<p class=\"gg-calypso-text anim-hidden fade-in-up\">Ectolysins have the following advantages over antibiotics</p>\r\n    </div>\r\n    \r\n    <ul class=\"fa-ul ml-0 pl-0\">\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Rapid Action</h2> <p class=\"ml-3\">Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Specific</h2> <p class=\"ml-3\">Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Mechanism of Action</h2> <p class=\"ml-3\">Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Bacterial Activity Independence</h2> <p class=\"ml-3\">Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Active on Biofilms</h2> <p class=\"ml-3\">Ectolysins are active both on planktonic bacteria &amp; bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-3\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> <h2 class=\"fw-900 gg-calypso-text ml-3\">Less Propensity for Resistance</h2> <p class=\"ml-3\">Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low.</p> \r\n    </ul>\r\n  </div>\r\n</div>\r\n\r\n'),
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(8409, 487, 'sections_2_content', '<div id=\"ectolysin-advantages\" class=\"gg-light\">\r\n  <div class=\"centerize ctz-lg px-3 py-5\">\r\n    <div class=\"text-center mb-4\">\r\n    	<h2 class=\"fw-900 gg-calypso-text anim-hidden fade-in-up\">Advantages of Ectolysins over Antibiotics</h2>\r\n    	<p class=\"gg-calypso-text anim-hidden fade-in-up\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins have the following advantages over antibiotics</p>\r\n    </div>\r\n    \r\n    <ul class=\"fa-ul\">\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Rapid Action</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Specific</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Mechanism of Action</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Bacterial Activity Independence</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Active on Biofilms</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins are active both on planktonic bacteria &amp; bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.</p>\r\n      <li class=\"anim-hidden fade-in-left mb-4\"><span class=\"fa-li\"><i class=\"fa fa-check gg-check\"></i></span> \r\n        <h3 class=\"fw-900 gg-calypso-text ml-3\">Less Propensity for Resistance</h3> \r\n        <p class=\"ml-3\" style=\"font-size:1.4rem; line-height:2;\">Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low.</p> \r\n    </ul>\r\n  </div>\r\n</div>\r\n\r\n'),
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