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      <h2 class="fw-900">Gram Negative Bacteriocins</h2>
      <p style="line-height:2; font-size:1.4rem;">Bacteriocins from Gram negative bacteria are broadly classified into 3 types based on their size as:</p>
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          <img style="height:190px;" class="mb-3" src="/wp-content/uploads/2020/09/2a.-Peptide-Bacteriocins.jpg.jpg" alt="peptide-bacteriocins" />
          <h3 class="gg-japanese-laurel-text mb-3">Peptide Bacteriocins</h3>
          <p>Peptide Bacteriocins like microcins of less than 10 kDa size</p>
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          <h3 class="gg-japanese-laurel-text mb-3">Colicin-Like Bacteriocins (CLB)</h3>
          <p>Colicin-Like Bacteriocins (CLB) of 25 – 80 kDa size</p>
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          <h3 class="gg-japanese-laurel-text mb-3">Tailocins</h3>
          <p>Tailocins which are high molecular size bacteriocins that resemble the tail structures of bacteriophages.</p>
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        	<h2 class="gg-calypso-text fw-900 anim-hidden fade-in-left">How Does It Work?</h2>
        	<p class="gg-calypso-text anim-hidden fade-in-left" style="font-size:1.4rem; line-height:2;">The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it.</p>
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        	<h2 class="gg-japanese-laurel-text fw-900 anim-hidden fade-in-right">Mechanism of Action</h2>
        	<p class="gg-japanese-laurel-text anim-hidden fade-in-right" style="font-size:1.4rem; line-height:2;">The mechanism of killing is through multiple modes such as cell wall damage, cell membrane damage, interfering in metabolic pathways, and DNase or RNase activities.</p>
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    	<h2 class="fw-900 abx-white-text anim-hidden fade-in-up">Advantages of Bacteriocins</h2>
    	<p class="abx-white-text anim-hidden fade-in-up" style="font-size:1.4rem; line-height:2;">Bacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Specific</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome.</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Resistance Development</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Selective</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents.</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Modular Architecture</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability.</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Low Toxicity</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.</p>
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        <h3 class="fw-900 gg-calypso-text ml-3">Synergy</h3> 
        <p class="ml-3" style="font-size:1.4rem; line-height:2;">The potency of bacteriocin can further be enhanced by combining them with standard of care antibiotics.</p>
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