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(23851, 936, 'sections_1_content', '<div id=\"bacteriophage-pipeline\">\r\n  \r\n  <div class=\"gg-japanese-laurel abx-white-text\">\r\n    <div class=\"centerize ctz-md px-3 py-5 text-center\">\r\n      <h2 class=\"anim-hidden fade-in-up\">Detection of adventitious phage contamination in Bacterial cell banks:</h2>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"gg-light\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n      <div>\r\n        <p class=\"gg-japanese-laurel-text anim-hidden fade-in-up\" style=\"line-height:2; font-size:1.4rem;\">GangaGen, with expertise in phage biology offers customized bacteriophage testing services to determine the presence or absence of phage contaminants in bacterial cell banks or production cells. Our team has more than fifteen years of experience and provides high quality phage testing services in tune with regulatory requirements in a timely manner. We offer both lytic and lysogenic phage detection for <em>E. coli</em> cell banks. Currently this service is offered as a Non-GLP activity.</p>\r\n      </div>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"abx-white\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n      <p class=\"gg-calypso-text anim-hidden fade-in-up\" style=\"line-height:2; font-size:1.4rem;\">The commercial production of recombinant biologicals and therapeutics is an important outcome of modern biotechnology. Selecting an ideal host bacterium to produce specific protein of interest is an important step in developing a production process. Widespread use of <em>E. coli</em> and other bacterial systems in biotechnology has led to the development of many different strains/cell lines. The process developed in production of therapeutics has to be taken to industrial scale to get viable industrial production mainly through fermentation technology.</p>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"gg-light\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n      <div>\r\n        <p class=\"gg-japanese-laurel-text anim-hidden fade-in-up\" style=\"line-height:2; font-size:1.4rem;\">The starting material for manufacturing includes a well characterized bacterial culture, known to be free from bacteriophage and is capable of expressing the protein product of interest in good measure. Production host bacterial cell “seed lot” system is used by manufacturers to assure identity and purity of the starting raw material viz., production host culture. A cell seed lot/research cell bank consists of aliquots of a single culture from where the <strong><em>“Master Cell Bank” (MCB)</em></strong> and <strong><em>“Working Cell Bank” (WCB)</em></strong> are derived. A well-characterized cell bank assures lot-to-lot consistency of the product. Regulatory agencies such as USFDA, EMEA require MCBs to adhere to ICH guidelines which emphasizes on characterization and testing to establish identity, purity and genetic stability of the cell line. A phage contaminated cell bank cannot be termed as <em>\"stable\"</em> as it may not generate the required cell density in a sustainable fashion during the fermentation process because of contaminating phages. Thus, it becomes essential to establish absence of phages in cell banks by conducting the prescribed battery of tests. </p>\r\n      </div>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"abx-white\">\r\n    <div class=\"centerize ctz-lg px-3 py-5\">\r\n      <div>\r\n        <h2 class=\"gg-calypso-text anim-hidden fade-in-up\">Bacteriophage Detection Services</h2>\r\n        <p class=\"gg-calypso-text anim-hidden fade-in-up\" style=\"line-height:2; font-size:1.4rem;\">We offer both lytic and lysogenic phage detection for <em>E. coli</em> cell banks. This service offered by GangaGen is an ISO-9001:2015 certified activity.</p>\r\n      </div>\r\n    </div>\r\n  </div>\r\n  \r\n  <div class=\"gg-calypso abx-white-text\">\r\n    <div class=\"centerize ctz-lg px-3 py-5 text-center\">\r\n      <h2 class=\"fw-900 anim-hidden fade-in-down animated visible fadeInDown full-visible\">For More Information:</h2>\r\n      <div class=\"text-center\">\r\n    	<a href=\"mailto:info@gangagen\"><button class=\"gangagen-button-clear anim-hidden fade-in-up animated visible fadeInUp full-visible\">Email</button></a>\r\n    	<a href=\"/contact\"><button class=\"gangagen-button-clear anim-hidden fade-in-up animated visible fadeInUp full-visible\">Contact Form</button></a>\r\n      </div>\r\n    </div>\r\n  </div>\r\n  \r\n</div>'),
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(412, 1, '2020-09-07 12:01:31', '2020-09-07 12:01:31', 'Bacteriocins from Gram negative bacteria are broadly classified into 3 types based on their size as:\n\n(i) Peptide bacteriocins like microcins of <10 kDa size, \n\n(ii) Colicin like bacteriocins (CLB) of 25 – 80 kDa size, and \n\n(iii) Tailocins which are high molecular size bacteriocins that resemble the tail structures of bacteriophages. \n\nThe CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \n\nThe mechanism of killing is through multiple modes like\nCell wall damage\nCell membrane damage\nBy interfering in metabolic pathways, \nDNase or RNase activities.\n\n\n\nBacteriocins - Advantages\n\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-autosave-v1', '', '', '2020-09-07 12:01:31', '2020-09-07 12:01:31', '', 236, 'http://gangagen.com/236-autosave-v1/', 0, 'revision', '', 0),
(413, 1, '2020-09-07 00:19:41', '2020-09-07 00:19:41', '	Bacteriocins from Gram negative bacteria are broadly classified into 3 types based on their size as – (i) Peptide bacteriocins like microcins of <10 kDa size, (ii) Colicin like bacteriocins (CLB) of 25 – 80 kDa size, and (iii) Tailocins which are high molecular size bacteriocins that resemble the tail structures of bacteriophages. The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \r\n\r\nThe mechanism of killing is through multiple modes like\r\nCell wall damage\r\nCell membrane damage\r\nBy interfering in metabolic pathways, \r\nDNase or RNase activities.\r\n\r\n\r\n\r\nBacteriocins - Advantages\r\n\r\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\r\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \r\n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\r\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \r\n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\r\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\r\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-revision-v1', '', '', '2020-09-07 00:19:41', '2020-09-07 00:19:41', '', 236, 'http://gangagen.com/236-revision-v1/', 0, 'revision', '', 0),
(414, 1, '2020-09-07 00:22:33', '2020-09-07 00:22:33', '', 'Protein Antibiotics: Lysins', '', 'inherit', 'closed', 'closed', '', '238-revision-v1', '', '', '2020-09-07 00:22:33', '2020-09-07 00:22:33', '', 238, 'http://gangagen.com/238-revision-v1/', 0, 'revision', '', 0),
(415, 1, '2020-09-07 00:24:52', '2020-09-07 00:24:52', 'Ectolysins help the phage gain entry from outside into the bacterial cell. Endolysins help the phage progeny to burst open & exit the bacterial cell. \r\n     More about Lysins- Link page\r\n\r\nGangaGen has used its proprietary PATP to design novel lysin molecules to target both Gram positive and Gram negative pathogens. The most advanced of these is P128 (Staphtame), an Ectolysin that is active on Staphylococci and progressed to clinical trials in man.', 'Protein Antibiotics: Lysins', '', 'inherit', 'closed', 'closed', '', '238-revision-v1', '', '', '2020-09-07 00:24:52', '2020-09-07 00:24:52', '', 238, 'http://gangagen.com/238-revision-v1/', 0, 'revision', '', 0),
(417, 1, '2020-09-07 00:32:52', '2020-09-07 00:32:52', 'Ectolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\n\r\n\r\n-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. ', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-07 00:32:52', '2020-09-07 00:32:52', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(418, 1, '2020-09-07 00:41:51', '2020-09-07 00:41:51', 'Bacteriophages (‘phages’ for short) are viruses that prey on bacteria.\r\n \r\nPhages are the most ubiquitous organisms on Earth, and they abound in natural as well as in man-made environments, where ever bacteria exist.\r\n \r\nGangaGen’s phage expertise and core bacteriophage technology is deployed towards developing safe and effective antibacterial products based on naturally-occurring bacteriophages. \r\n\r\nGangaGen has developed methods to rapidly isolate phages effective on a given species of bacteria.\r\nGangagen has developed methods to characterise phages and build effective custom cocktails against different pathogenic bacteria.\r\n\r\nAdditionally, GangaGen’s expertise allows making phage preparations fit for therapeutic application, with fully developed, scalable processes for production and purification, and analytical methods for quality control of bacteriophage lots.\r\n\r\nGBPL is equipped with a library of ~500 phages and 3000 bacterial strains belonging to various genera, which is updated periodically. ', 'Protein Antibiotics: Bacteriophage', '', 'inherit', 'closed', 'closed', '', '240-revision-v1', '', '', '2020-09-07 00:41:51', '2020-09-07 00:41:51', '', 240, 'http://gangagen.com/240-revision-v1/', 0, 'revision', '', 0),
(420, 1, '2020-09-07 00:50:49', '2020-09-07 00:50:49', '', 'Bacteriophages: Novel Applications', '', 'inherit', 'closed', 'closed', '', '242-revision-v1', '', '', '2020-09-07 00:50:49', '2020-09-07 00:50:49', '', 242, 'http://gangagen.com/242-revision-v1/', 0, 'revision', '', 0),
(421, 1, '2020-09-07 00:51:39', '2020-09-07 00:51:39', 'Novel applications\r\n\r\nPhages can be used to control undesirable bacteria in various settings where bacteria may cause disease, contamination, disturbance or imbalance in natural microbiomes, or other problems. Gangagen has also used phages to tackle eniviorment related challenges.\r\n\r\nFood safety	\r\n\r\nBacteriophages are ideally suited natural antimicrobials for controlling bacterial pathogens in agro-food industry and their effectiveness is proven. Phage products have been approved by the USDA for use in farm animals or animal products such as carcasses, meats and also in agricultural and horticultural products. The common zoonotic bacterial pathogens that are often resistant to several antibiotics and associated with poultry and pigs include Salmonella spp., Campylobacter spp., E. coli, Clostridium spp. and Listeria spp. \r\n\r\nVeterinary Applications: \r\n\r\nAntibiotic resistance is a significant problem within the veterinary sector. Otitis externa is a common complaint in dogs, involving inflammation of the external ear canal.  Antibiotic treatment is often ineffective due to the bacterium’s resistance to many classes of antibiotics. Phages are ideally suited for the treatment of this infection. \r\nAnother major veterinary medicine application of phage is in canine pyoderma, which is the most commonly diagnosed skin infection within small veterinary practices. Phage is promising for these, especially since most isolates implicated are multidrug-resistant (MDR).', 'Bacteriophages: Novel Applications', '', 'inherit', 'closed', 'closed', '', '242-revision-v1', '', '', '2020-09-07 00:51:39', '2020-09-07 00:51:39', '', 242, 'http://gangagen.com/242-revision-v1/', 0, 'revision', '', 0),
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(432, 1, '2020-09-07 12:26:15', '2020-09-07 12:26:15', '\r\nThe CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \r\n\r\nThe mechanism of killing is through multiple modes like\r\nCell wall damage\r\nCell membrane damage\r\nBy interfering in metabolic pathways, \r\nDNase or RNase activities.\r\n\r\n\r\n\r\nBacteriocins - Advantages\r\n\r\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\r\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \r\n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\r\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \r\n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\r\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\r\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-revision-v1', '', '', '2020-09-07 12:26:15', '2020-09-07 12:26:15', '', 236, 'http://gangagen.com/236-revision-v1/', 0, 'revision', '', 0),
(433, 1, '2020-09-07 12:42:16', '2020-09-07 12:42:16', 'The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \r\n\r\nThe mechanism of killing is through multiple modes like\r\nCell wall damage\r\nCell membrane damage\r\nBy interfering in metabolic pathways, \r\nDNase or RNase activities.\r\n\r\n\r\n\r\nBacteriocins - Advantages\r\n\r\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\r\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \r\n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\r\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \r\n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\r\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\r\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-revision-v1', '', '', '2020-09-07 12:42:16', '2020-09-07 12:42:16', '', 236, 'http://gangagen.com/236-revision-v1/', 0, 'revision', '', 0),
(434, 1, '2020-09-07 12:43:41', '2020-09-07 12:43:41', 'The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \r\n\r\nThe mechanism of killing is through multiple modes like\r\nCell wall damage\r\nCell membrane damage\r\nBy interfering in metabolic pathways, \r\nDNase or RNase activities.\r\n\r\n\r\n\r\nBacteriocins - Advantages\r\n\r\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\r\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \r\n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\r\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \r\n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\r\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\r\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-revision-v1', '', '', '2020-09-07 12:43:41', '2020-09-07 12:43:41', '', 236, 'http://gangagen.com/236-revision-v1/', 0, 'revision', '', 0),
(435, 1, '2020-09-07 12:44:35', '2020-09-07 12:44:35', 'The CLBs entry into the bacterial cell is mediated through its interaction with cell-surface receptors, and thus conferring both specificity and selectivity. The Bacteriocin producing bacterium is protected from its own action by an immunity protein co-expressed with it. \r\n\r\nThe mechanism of killing is through multiple modes like\r\nCell wall damage\r\nCell membrane damage\r\nBy interfering in metabolic pathways, \r\nDNase or RNase activities.\r\n\r\n\r\n\r\nBacteriocins - Advantages\r\n\r\nBacteriocins offer several advantages over antibiotics making them attractive starting points for developing anti-bacterial agents:\r\n	(i) 	Specific - Their specificity offers a targeted approach and kills only the target pathogen, without damaging the commensal human microbiota or microbiome. \r\n	(ii) 	Resistance development – The Bacteriocins have a unique mode of action and hence there is no primed resistance in the bacterial community.\r\n	(iii) Selective- Bacteriocins enter the bacterial cell through specific receptors which are absent on eukaryotic cells and hence are very selective agents. \r\n	(iv) Modular architecture – The colicin like bacteriocins (CLB) have modular domain structure that can be engineered to generate new bacteriocins with enhanced functionalities like activity/stability\r\n	(v) 	Low toxicity – For generations the commensal bacteria in human body has been employing the bacteriocins to ward off invasions by pathogenic bacteria, hence natural bacteriocins can be expected to be safe to Humans.\r\n	(vi) Synergy - The potency of Bacteriocin can further be enhanced by combining them with standard of care antibiotics', 'Protein Antibiotic: Bacteriocins', '', 'inherit', 'closed', 'closed', '', '236-revision-v1', '', '', '2020-09-07 12:44:35', '2020-09-07 12:44:35', '', 236, 'http://gangagen.com/236-revision-v1/', 0, 'revision', '', 0),
(436, 1, '2020-09-07 14:14:20', '2020-09-07 14:14:20', 'GangaGen’s bacteriophage technology platform includes a library of ~ 500 phages and a collection of ~3000 clinical isolates of diverse pathogens. \n\nAdditionally GBPL has extensive experience in phage isolation, phage engineering, developing phage cocktails and manufacture of phages for different applications. \n\nIn 2007, GangaGen made a strategic decision to focus ‘bacteriophage technology’ for novel non-human applications. These applications include: More information – visit Link page\nFood safety\nVeterinary\nEnvironment\nPlants and crops\n\n', 'Phage Technology: Applications', '', 'inherit', 'closed', 'closed', '', '266-autosave-v1', '', '', '2020-09-07 14:14:20', '2020-09-07 14:14:20', '', 266, 'http://gangagen.com/266-autosave-v1/', 0, 'revision', '', 0),
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(446, 1, '2020-09-08 18:40:09', '2020-09-08 18:40:09', '', 'Research Publications', '', 'inherit', 'closed', 'closed', '', '296-revision-v1', '', '', '2020-09-08 18:40:09', '2020-09-08 18:40:09', '', 296, 'http://gangagen.com/296-revision-v1/', 0, 'revision', '', 0),
(447, 1, '2020-09-08 18:54:09', '2020-09-08 18:54:09', 'Ectolysins help the phage gain entry from outside into the bacterial cell. Endolysins help the phage progeny to burst open & exit the bacterial cell. \r\n     More about Lysins- Link page\r\n\r\nGangaGen has used its proprietary PATP to design novel lysin molecules to target both Gram positive and Gram negative pathogens. The most advanced of these is P128 (Staphtame), an Ectolysin that is active on Staphylococci and progressed to clinical trials in man.', 'Protein Antibiotics: Lysins', '', 'inherit', 'closed', 'closed', '', '238-revision-v1', '', '', '2020-09-08 18:54:09', '2020-09-08 18:54:09', '', 238, 'http://gangagen.com/238-revision-v1/', 0, 'revision', '', 0),
(448, 1, '2020-09-08 18:59:24', '2020-09-08 18:59:24', 'Ectolysins help the phage gain entry from outside into the bacterial cell. Endolysins help the phage progeny to burst open & exit the bacterial cell. \r\n     More about Lysins- Link page\r\n\r\nGangaGen has used its proprietary PATP to design novel lysin molecules to target both Gram positive and Gram negative pathogens. The most advanced of these is P128 (Staphtame), an Ectolysin that is active on Staphylococci and progressed to clinical trials in man.', 'Protein Antibiotics: Lysins', '', 'inherit', 'closed', 'closed', '', '238-revision-v1', '', '', '2020-09-08 18:59:24', '2020-09-08 18:59:24', '', 238, 'http://gangagen.com/238-revision-v1/', 0, 'revision', '', 0),
(449, 1, '2020-09-08 18:59:46', '2020-09-08 18:59:46', 'Ectolysins help the phage gain entry from outside into the bacterial cell. Endolysins help the phage progeny to burst open & exit the bacterial cell. \r\n     More about Lysins- Link page\r\n\r\nGangaGen has used its proprietary PATP to design novel lysin molecules to target both Gram positive and Gram negative pathogens. The most advanced of these is P128 (Staphtame), an Ectolysin that is active on Staphylococci and progressed to clinical trials in man.', 'Protein Antibiotics: Lysins', '', 'inherit', 'closed', 'closed', '', '238-revision-v1', '', '', '2020-09-08 18:59:46', '2020-09-08 18:59:46', '', 238, 'http://gangagen.com/238-revision-v1/', 0, 'revision', '', 0),
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(475, 1, '2020-09-09 02:25:56', '2020-09-09 02:25:56', 'Antibiotic resistance is a significant problem within the veterinary sector. Otitis externa is a common complaint in dogs, involving inflammation of the external ear canal.  Antibiotic treatment is often ineffective due to the bacterium’s resistance to many classes of antibiotics. Phages are ideally suited for the treatment of this infection. \r\n\r\nAnother major veterinary medicine application of phage is in canine pyoderma, which is the most commonly diagnosed skin infection within small veterinary practices. Phage is promising for these, especially since most isolates implicated are multidrug-resistant (MDR).', 'Phage Technology: Veterinary', '', 'inherit', 'closed', 'closed', '', '268-revision-v1', '', '', '2020-09-09 02:25:56', '2020-09-09 02:25:56', '', 268, 'http://gangagen.com/268-revision-v1/', 0, 'revision', '', 0),
(476, 1, '2020-09-09 02:26:38', '2020-09-09 02:26:38', 'Bacteriophages are ideally suited natural antimicrobials for controlling bacterial pathogens in agro-food industry and their effectiveness is proven. Phage products have been approved by the USDA for use in farm animals or animal products such as carcasses, meats and also in agricultural and horticultural products. The common zoonotic bacterial pathogens that are often resistant to several antibiotics and associated with poultry and pigs include Salmonella spp., Campylobacter spp., E. coli, Clostridium spp. and Listeria spp.', 'Phage Technology: Food Safety', '', 'inherit', 'closed', 'closed', '', '270-revision-v1', '', '', '2020-09-09 02:26:38', '2020-09-09 02:26:38', '', 270, 'http://gangagen.com/270-revision-v1/', 0, 'revision', '', 0),
(477, 1, '2020-09-09 02:32:27', '2020-09-09 02:32:27', 'Ectolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\n\r\n\r\n-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-09 02:32:27', '2020-09-09 02:32:27', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(478, 1, '2020-09-11 21:52:49', '2020-09-11 21:52:49', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 21:52:49', '2020-09-11 21:52:49', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(479, 1, '2020-09-11 21:53:39', '2020-09-11 21:53:39', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 21:53:39', '2020-09-11 21:53:39', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(480, 1, '2020-09-11 21:54:02', '2020-09-11 21:54:02', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 21:54:02', '2020-09-11 21:54:02', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(481, 1, '2020-09-11 22:05:19', '2020-09-11 22:05:19', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:05:19', '2020-09-11 22:05:19', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0);
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(482, 1, '2020-09-11 22:11:56', '2020-09-11 22:11:56', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:11:56', '2020-09-11 22:11:56', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(483, 1, '2020-09-11 22:20:05', '2020-09-11 22:20:05', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:20:05', '2020-09-11 22:20:05', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(484, 1, '2020-09-11 22:22:48', '2020-09-11 22:22:48', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:22:48', '2020-09-11 22:22:48', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(485, 1, '2020-09-11 22:23:42', '2020-09-11 22:23:42', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:23:42', '2020-09-11 22:23:42', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(486, 1, '2020-09-11 22:25:43', '2020-09-11 22:25:43', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications. \r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-11 22:25:43', '2020-09-11 22:25:43', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
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(525, 1, '2020-09-14 00:21:07', '2020-09-14 00:21:07', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\n\r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\n\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-14 00:21:07', '2020-09-14 00:21:07', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0);
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(526, 1, '2020-09-14 00:21:57', '2020-09-14 00:21:57', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\n\r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\n\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-14 00:21:57', '2020-09-14 00:21:57', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
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(529, 1, '2020-09-14 00:33:45', '2020-09-14 00:33:45', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\n\r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\n\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-14 00:33:45', '2020-09-14 00:33:45', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
(530, 1, '2020-09-14 00:35:51', '2020-09-14 00:35:51', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\n\r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\n\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-14 00:35:51', '2020-09-14 00:35:51', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
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(535, 1, '2020-09-14 00:39:44', '2020-09-14 00:39:44', '-- Ectolysins are phage structural proteins, which enable phages to penetrate the bacterial cell. They cleave specific chemical bonds on the bacterial cell wall, leading to bacterial lysis and death. \r\n-- Ectolysins have the following advantages over antibiotics\r\n1) Rapid action - Ectolysins are rapid acting and cleave the cell wall immediately on contact, within minutes, as against antibiotics that need longer duration to kill the cells.\r\n2) Specific - Ectolysins are very specific to the target bacterial species and hence kill only the target pathogen without affecting the microbiome or the commensal bacterial flora as compared to antibiotics which kill both the pathogens as well as the beneficial bacteria.\r\n3) Mechanism of action – Ectolysins have novel mode of action- they include enzymatic mechanisms like Muramidase, Glucosaminidase, Amidase or endopeptidase depending upon the cell wall bond targeted by the individual ectolysin.  The availability of a library of enzymatic domains offers the opportunity of protein engineering.\r\n4) Bactericidal activity is not dependent on the metabolic stage of the cell – Ectolysins kill both actively growing as well as stationary phase cells irrespective of the metabolic state. But antibiotics act only on metabolically active cells.\r\n5) Active on Biofilms – Ectolysins are active both on planktonic bacteria & bacterial biofilms as against antibiotics, which act poorly on bacterial biofilms.\r\n6) Less propensity for resistance- Ectolysins cleave essential cell wall chemical bonds, which are highly conserved and omnipresent on the bacterial cell surface; hence the propensity for the development of bacterial resistance is low. \r\n\r\n\r\n\r\n\r\n\r\nEctolysins Against Gram Positive Bacteria\r\n\r\nEctolysins against Staphylococcus: \r\nEctolysin P128, GangaGen’s lead molecule is a chimeric recombinant anti-staphylococcal protein that targets both coagulase positive and coagulase negative Staphylococci. \r\nP128 has a novel mechanism of action and rapidly kills Staphylococci.\r\nIt is proven to be very effective both in vitro & in vivo against multidrug resistant pathogens like Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Staphylococcus aureus (VRSA) and Daptomycin Resistant Staphylococcus aureus (DRSA). GangaGen has completed Phase I/IIA studies with P128 for ‘nasal decontamination of S. aureus’ from human nares.\r\n	(Learn more about P128 here. Link  page)\r\n\r\nEctolysins against Enterococcus:\r\nGangaGen has used PATP to discover and engineer novel ectolysins suitable for multiple applications.\r\n\r\n\r\n\r\nEctolysins Against Gram Negative Bacteria\r\n\r\nThe development of ectolysins against Gram negative bacteria is a challenge due to the presence of impermeable outer membrane that prevents access to the Gram negative peptidoglycan layer of the cell wall.\r\n\r\nGangaGen has successfully overcome this challenge to discover and engineer lysins with broad spectrum activity against human pathogens such as Acinetobacter baumannii and Pseudomonas aeruginosa.\r\n\r\nGangaGen\'s Gram negative ectolysins are potent in extensive in vitro studies including demonstrated activity in relevant biological fluids and in vivo studies. GangaGen aims to develop these ectolysins as an intravenous therapeutic for human applications.\r\n\r\n', 'Protein Antibiotics: Ectolysin', '', 'inherit', 'closed', 'closed', '', '257-revision-v1', '', '', '2020-09-14 00:39:44', '2020-09-14 00:39:44', '', 257, 'http://gangagen.com/257-revision-v1/', 0, 'revision', '', 0),
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(588, 1, '2020-09-14 02:55:22', '2020-09-14 02:55:22', 'Novel applications\r\n\r\nPhages can be used to control undesirable bacteria in various settings where bacteria may cause disease, contamination, disturbance or imbalance in natural microbiomes, or other problems. Gangagen has also used phages to tackle eniviorment related challenges.\r\n\r\nFood safety	\r\n\r\nBacteriophages are ideally suited natural antimicrobials for controlling bacterial pathogens in agro-food industry and their effectiveness is proven. Phage products have been approved by the USDA for use in farm animals or animal products such as carcasses, meats and also in agricultural and horticultural products. The common zoonotic bacterial pathogens that are often resistant to several antibiotics and associated with poultry and pigs include Salmonella spp., Campylobacter spp., E. coli, Clostridium spp. and Listeria spp. \r\n\r\nVeterinary Applications: \r\n\r\nAntibiotic resistance is a significant problem within the veterinary sector. Otitis externa is a common complaint in dogs, involving inflammation of the external ear canal.  Antibiotic treatment is often ineffective due to the bacterium’s resistance to many classes of antibiotics. Phages are ideally suited for the treatment of this infection. \r\nAnother major veterinary medicine application of phage is in canine pyoderma, which is the most commonly diagnosed skin infection within small veterinary practices. Phage is promising for these, especially since most isolates implicated are multidrug-resistant (MDR).', 'Bacteriophages: Novel Applications', '', 'inherit', 'closed', 'closed', '', '242-revision-v1', '', '', '2020-09-14 02:55:22', '2020-09-14 02:55:22', '', 242, 'http://gangagen.com/242-revision-v1/', 0, 'revision', '', 0),
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